Tuesday, October 25, 2022

7:00 - 8:15 AM

Breakfast - La Terraza

8:30 - 10:30 AM

Chair(s): Jordi Duran (Spain) and Phil Lee (USA)

Student-Postdoctoral fellow award presentations (listed in order of presentation)

Lumpkin Ballroom

1. Nerve terminal PGK1 is a critical control point for fueling synaptic function - Alexandros Kokotos, Weill Cornell Medicine, New York, New York, USA
2. The effect of acute ATP depletion on synaptic vesicle endocytosis at the ultrastructural level - Quan Gan, Johns Hopkins University, Baltimore, Maryland, USA
3. Frequency dependence of ATP generating pathways in an auditory brainstem nucleus - Nicola Palandt, Ludwig Maximilian University of Munich, Germany
4. Mass spectrometry imaging reveals dentate granule neuron fuel use during rest and stimulation - Elisa York, Harvard Medical School, Cambridge, Massachusetts, USA
5. GABA mediates a Warburg-like shift of neuronal metabolism from OXPHOS to glycolysis - Bernhard Groschup, Institute For Stroke and Dementia Research, Munich, Germany
6. Impaired GABA metabolism in Alzheimer’s disease - Jens Andersen, University of Copenhagen, Copenhagen, Denmark
7. Obesity and prodromal Alzheimer's brain metabolism - Thea Anderson, Georgia State University, Atlanta, Georgia, USA
8. Brain insulin signalling and GLUT4 expression are altered in the chronic stage of mouse pilocarpine model of epilepsy - Weizhi Xu. The University of Queensland, Brisbane, Australia
9. Lafora disease: a metabolic fingerprint in mouse and human - Kia Markussen, University of Kentucky, Lexington, Kentucky, USA
10. Adaptations of fatty acid metabolism after neonatal brain injury - Regina Fernandez, Johns Hopkins University, Baltimore, MD, USA
11. Microglia-derived energy metabolism distinct patterns under fatty acid remodeling - Gabriela De Paula, Lund University, Lund, Sweden
12. Inflammation-induced microglial nitric oxide production is glucose dependent - Gökhan Uruk, UCSF, San Francisco, California, USA

10:30 - 11:00 AM

Coffee break

11:00 AM - 12:30 PM

Chair(s): Arne Schousboe (Denmark) and Mukesh Kumar (USA)

Session 1. Neuronal energetics: Ion pumping and signaling, memory

Lumpkin Ballroom

• Hypersensitive control of mitochondrial ATP production in neurons involves the Na+ pump - L. Felipe Barros, Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile
• Calcium fluxes and ion pumping orchestrate NADH production in stimulated neurons - Carlos Diaz-Garcia, University of Oklahoma, Oklahoma City, Oklahoma, USA
• Insulin-signaling upregulates GLUT4 in hippocampal neurons: required for memory - Ewan McNay, University of Albany, Albany, New York, USA

12:30 - 1:30 PM

Buffet Lunch - La Terraza

1:30 PM - 3:00 PM

Chair(s): Raymond A. Swanson (USA) and Regina Fernandez (USA)

Session 2. Beyond glucose storage: Glycogen involved in neuronal activation, learning/memory, seizures

Lumpkin Ballroom

• Astrocytic glycogenolysis spares glucose for neurons during activation - Douglas L. Rothman, Yale University, New Haven, Connecticut, USA
• Brain glycogen - more than just a glucose cache - Matthew Gentry, University of Kentucky, Lexington, Kentucky, USA
• Dissecting the specific roles of astrocytic and neuronal glycogen in memory formation, synaptic plasticity and glycogen-induced neurodegeneration - Jordi Duran, Instituto Químico de Sarriá Barcelona & Institute for Bioengineering of Catalonia, Barcelona, Spain

3:00 - 3:30 PM

Coffee break

3:30 - 5:00 PM

Chair(s): In-Young Choi (USA) and L. Felipe Barros (Chile)

Student/postdoc "Poster Power Pitch"

Lumpkin Ballroom

• Neal Bennet - Gladstone Institutes, San Francisco, California, USA
• Antoine Cherix - University of Oxford, Oxford, UK
• Isabel Christie - University College London, London, UK
• Khanh Doan - Yonsei University College of Dentistry, Seoul, South Korea
• Ashwini Hariharan - University of Maryland Baltimore, Baltimore, Maryland, USA
• Mukesh Kumar - Weill Cornell Medical College, New York, New York, USA
• Dasfne Lee-Liu - University of Chile, Santiago, Chile
• Sanna Loppi - University of Arizona, Phoenix, Arizona, USA
• Anne Miller - Harvard Medical School, Cambridge, Massachusetts, USA
• Hung Nguyen - Oregon Health & Science University, Portland, Oregon, USA
• Shefeeq Theparambil - University College London, London, UK
• Sarah Zerimech - Oregon Health & Science University, Portland, Oregon, USA
• Cory White - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
• Afroditi Eleftheriou - University of Zurich, Zurich, Switzerland
• Kirsten Bredvik - Weill Cornell Medical College, New York, New York, USA
• Bernardo Antunes - Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal
• Starlette Douglass - SUNY University at Albany, Albany, New York, USA
• Fernando Gonzalez Ibanez - Université Laval-University, Quebec City, Canada; University of Victoria, Victoria, BC, Canada
• Jimmy Harrison - University of Kentucky, Lexington, Kentucky, USA
• Sarah Kaye - Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
• Martin Woergaard Kjaer - University of Copenhagen, Copenhagen, Denmark
• Marisa Mekkittikul - University of California Los Angeles, Los Angeles, California, USA
• Mitchell Moyer - University of Maryland, College Park, Maryland, USA
• Lilian Oliveira - University of São Paulo, São Paulo, Brazil
• Alexandra von Faber-Castell - University of Zurich, Zurich, Switzerland
• Christopher Ware - Georgia State University, Atlanta, Georgia, USA
• Emil Westi - University of Copenhagen, Copenhagen, Denmark
• Diana Frida De Lima - Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
• Ivonne Romero Flores - Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
• Kenneth Oparaji - Alex Ekwueme Federal University Ndufu-Alike, Ndufu, Alike Ikwo of Ebonyi State, Nigeria
• Ochuko Erukainure - University of the Free State, Bloemfontein, South Africa
• Jae Hyouk Choi - University of California San Diego, La Jolla, California, USA

5:00 - 7:00 PM

Poster session I - Lumpkin Ballroom

7:00 - 8:00 PM

Dinner - La Terraza

8:00 - 10:00 PM

Poster session II - Lumpkin Ballroom

Wednesday, October 26, 2022

7:00 - 8:15 AM

Breakfast - La Terraza

8:30 - 10:00 AM

Chair(s): Michael Robinson (USA) and Kia Markussen (USA)

Session 3. Higher brain functions: Astrocyte-neuron interactions, cognition, and memory

Lumpkin Ballroom

• Astrocytic modulation of neuronal activity in recent and remote memory (presented over Zoom) - Adi Kol, Inbal Goshen Lab, Hebrew University, Jerusalem, Israel
• Locus coeruleus noradrenergic astrocytic excitation, gliotransmission, and cognitive decline in aging and Alzheimer's disease - Robert Zorec, University of Ljubljana, Ljubljana, Slovenia
• Energetics of hippocampal gamma oscillations that underlie cognitive functions - Oliver Kann, University of Heidelberg, Heidelberg, Germany

10:00 - 10:30 AM

Coffee break

10:30 AM - 12:00 PM

Chair(s): Nina Vardjan (Slovenia) and Bernhard Groschup (Germany)

Session 4. Dietary intervention: Impact on aging, memory, and Alzheimer's disease

Lumpkin Ballroom

• Bioactive foods modulate the release of bacterial products: prevention of neuroinflammation and cognitive decline in an Alzheimer mouse model (presented over Zoom) - Claudia Perez-Cruz, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), Mexico City, Mexico
• NAD and energy metabolism in mammalian tissues - Joseph Baur, University of Pennsylvania, Philadelphia, Pennsylvania, USA
• Dietary ketone ester: Neuroprotective in Alzheimer model mice and performance enhancer - Robert Pawlosky, Laboratory of Metabolic Control, National Institute of Alcohol Abuse and Alcoholism/National Institutes of Health, Bethesda, Maryland, USA

12:00 - 1:00 PM

Buffet Lunch

La Terraza

1:00 - 2:30 PM

Chair(s): Mary C. McKenna (USA) and Gabriela De Paula (Sweden)

Session 5. Gut-brain signaling: Microbiome influences higher brain functions

Lumpkin Ballroom

• Sensory transduction in the gut - Melanie Kaelberer, D. Bohórquez Lab, Duke University, Durham, North Carolina, USA
• Gut microbiome mediates effects of ketogenic diet: anti-seizure activity and hippocampal GABA/glutamate levels - Christine Olson, P. Turnbaugh Lab, University of California San Francisco, San Francisco, California, USA
• Host-microbe interactions regulating synaptic plasticity and behavior - Shelly Buffington, University of Texas Medical Branch, Galveston, Texas, USA

2:30 - 3:00 PM

• ISN Announcement (Caroline "Lindy" Rae)
• Journal of Neurochemistry student poster awards (Mary McKenna)
• A tribute to Sebastian Cerdan (Mary McKenna)

La Terraza

3:00 - 3:30 PM

Coffee Break

3:30 - 5:00 PM

Chair(s): Caroline (Lindy) Rae (Australia) and Bernardo Antunes (Portugal)

Session 6. Mitochondria and their metabolites: Sleep, neurotransmission, and memory

Lumpkin Ballroom

• α-Ketoglutarate couples TCA cycle with synaptic transmission in photoreceptors and neuromuscular junction (presented over Zoom) - Berrak Ugur, P. De Camilli Lab., Yale University, New Haven, Connecticut, USA
• Energy metabolism, mitochondrial redox state, and sleep - Gero Miesenböck, University of Oxford, Oxford, UK
• Cannabinoid CBR1 receptors govern mitochondrial metabolism and memory - Ignacio Fernandez Moncada, National Institute of Health and Medical Research (INSERM), University of Bordeaux, Bordeaux, France

5:00 - 6:00 PM

Chair(s): C. William Shuttleworth (USA)

Thinking about sensors: Principles and practice of fluorescent biosensor quantitation and interpretation

Lumpkin Ballroom

Functional principles of fluorescent biosensor development and their quantitative use - Dorothy Koveal, Georgia Tech, Atlanta, Georgia, USA

6:00 - 7:30 PM

Dinner - La Terraza

7:30 - 9:00 PM

Chair(s): Kelly Drew (USA) and Jens Andersen (Denmark)

Session 7. Metabolic neuroimaging in aging and neurodegeneration

Lumpkin Ballroom

• Cerebral metabolic changes and influencing factors in aging and neurodegeneration - Phil Lee, University of Kansas Medical Center, Kansas City, Kansas, USA
• Hormone-sensitive lipase contributes for brain metabolism regulation, and its deletion impairs memory in aged mice - João M. N. Duarte, Lund University, Lund, Sweden
• Quantitative study of human brain aging and neurodegeneration using advanced neurometabolic imaging - Wei Chen, University of Minnesota, Minneapolis, Minnesota, USA