WELCOME & ANNOUNCEMENTS

• Welcome & Acknowledgements from the Program Committee 
• Information about ISN 
• Information about ISCBFM - Kelly Drew, PhD
• Welcome from the Organizing Committee & Presentation of the Safety Plan

Thomas Longden, PhD, University of Maryland

• Oxygenation of blood w/ functional activation - Sava Sakazdik, PhD, Harvard University
• Cerebrovascular endothelial cell mitochondrial dysfunction in Alzheimer's disease - Rebecca Parodi-Rullán, PhD, Temple University
• Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure - Andy Shih, PhD, Seattle Children's Hospital

SYMPOSIUM 3: The Glia-Neuron Gossip: Secrets of Cellular Communication

• Metabolic interactions between astroglial CB1R receptors, the lactate receptor HCA1R and serine: Who’s in control? - Ignacio Fernandez-Moncada, PhD, INSERM
• Abeta increases astrocyte IDO1 to restore lactate production - Katrin Andreasson, PhD, Stanford University
• Adenosine signaling to astrocytes coordinates brain metabolism and function - Alexander Gourine, PhD, University College of London
• Alterations in the neuronal /glial energy budget with aging and AD - Clare Howarth, PhD, MSci, University of Sheffield

SYMPOSIUM 4: Microglial metabolism: Fueling the fire or fighting it?

• Hexokinase 2 and glycolysis in microglial activation - Gary Landreth, PhD, Indiana University
• Complex 1 sustains microglial activity in inflammation - Stefano Pluchino, PhD, University of Cambridge
• Neuronal AMPK regulates lipid transport to microglia - Maria Ioannou, PhD, University of Alberta

SYMPOSIUM 5: The unexpected roles of neuronal glycolysis

• Weak neuronal glycolysis sustains cognition - Marina Garcia Macia, PhD, University de Salamanca
• Aerobic glycolysis in neuronal somata protects against oxidative damage - TBD
• Glycolytic shifts in neurodegeneration - Ken Nakamura, PhD, Gladstone Institute/UCSF
• Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition in astrocytes and neurons - Eduardo Balsa, PhD, Universidad Autonoma de Madrid

SYMPOSIUM 6: When astrocytes lose their grip on fatty acids

• Loss of FA degradation by astrocytes mitos -> inflammation and neurodegeneration - Fei Yin, PhD, University of Arizona

• Neuron-glia lipids metabolic cycle couples sleep to mitochondrial function - Amita Sehgal, PhD, University of Pennsylvania
• Aging Brain Fatty Acid Metabolism, Acsl6 is required for DHA retention in the brain - Jessica Ellis, PhD, East Carolina University

SYMPOSIUM 7: Ketones: novel roles for brain’s alternative substrates

• Gut microbial effects on brain ketone availability in AD etc. - TBD
• Acetate compensates for sleep disruption w/r to hippocampal neuroplasticity - TBD
• β-hydroxybutyrate regulates proeostasis - Josh Newman, MD, PhD, Buck Institute of Aging

SYMPOSIUM 8: Targeting bioenergetics in the ageing neuron

• Mitochondrial surveillance in neuronal homeostasis and neurodegenerative disease - TBD 
• APOE4 exacerbates plaque-induced microglial reactivity and lipid metabolism - Lance Johnson, PhD, University of Kentucky
• LXR against ameliorates glial lipid accumulation and neurodegeneration in AD - TBD

SYMPOSIUM 9: Interactive discussion on key and/or emerging areas that need more research

Facilitators: Ray Swanson, Lindy Rae, Mary McKenna and Joao Duarte